Research Scientist/ Senior Research Scientist

Company: AstraZeneca
Location: Gaithersburg
Posted on: October 19, 2020

Job Description:

Research Scientist/ Senior Research Scientist

AstraZeneca is a British-Swedish multinational pharmaceutical and biopharmaceutical company. Here, you'll have the opportunity to collaborate with renowned scientists to find the targets which are fundamental drivers of human disease. As one of the world's premier biotechnology companies, our mission is centered on groundbreaking, outstanding work that has a big impact on science and making a difference in people's lives every day.

What youll do

As a Senior Research Scientist in the COPD research team in the Respiratory and Immunology department (R&I) you will study the biology of human airway and alveolar epithelium with the focus on lung stem cells, immune cells, and pathogenesis of COPD disease. You will study growth factor pathways that regulate lung stem cell self-renewal and differentiation in health and disease, epithelial-mesenchymal and epithelial-immune interactions using patient airway models and patient-derived iPSCs at the tissue- and single-cell levels.

you will also provide scientific input to the early stage of research and development. This includes study design, analysis, and interpretation of preclinical data and mechanistic studies in human-based 3D culture systems or animal models.

Collaboration with colleagues within and beyond early R&I will be crucial for you to be successful in your role and you will work closely together with colleagues from Patient Safety, Discovery science, Translational science, and late R&I Groups.

We will rely on you to:

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• Lead and perform a range of lab-based experiments including generating 2D and 3D culture models, phenotyping diseased cells with cellular, molecular and functional assays.
• Isolated and utilized epithelial cells and immune cells from patients samples
• Make detailed observations, analyze data, and interpret results independently.
• Preparation of precise technical summaries, protocols, quantitative analyses, and maintenance of appropriate documentation.
• Oversee the day to day organization of different components of the projects.
• Work collaboratively with other members of the teams who are working on related research questions.
• Publish discoveries in high quality and impact journals.
  
  Essential for the role:
  
  Research Scientist
  
  Ph.D. in the field of cell biology, Molecular biology , immunology or a related field with 3-4 years postdoc or industry experience
  
  Senior Research Scientist
  
  Ph.D. in the field of Cell biology, Immunology, Molecular biology or a related field with 5-6 years postdoc or industry experience
  
  Additionally, you possess:
  
  • 
    
  • The knowledge of lung biology, physiology, and disease, epithelial, and mesenchymal biology.
  • Experience in stem cell culture and differentiation.
  • Strong cell biology experience in tissue culture techniques, isolation, and culture of primary cells and the use of co-culture systems.
  • Excellent skills in cellular and molecular biology techniques (Western blot, qRT-PCR, immunostaining, ELISA) and fluorescence imaging.
  • Excellent analytic and problem-solving skills.
  • Excellent written and verbal interpersonal skills and effective presentation of complex scientific data to cross-functional and senior management teams
  • Proven ability to work independently and in collaborative team environments
    
    Desirablefor the role
    
    • 
      
    • Experience in advanced 3D imaging and single-cell RNA seq analysis.
    • Experience in bioinformatics analysis and software
    • Experience in the development of the in-vitro disease model and in vivo mouse models and subsequent analysis, including but not limited to COPD is a plus.
    • Experience of leading and managing small group and cross-functional collaboration activities
      
      At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means were opening new ways to work, pioneering groundbreaking methods and bringing unexpected teams together. Interested? Come and join our journey!
      
      So, whats next!
      
      If you are ready to make a difference - apply today, and we'll make it happen together!
      
      We welcome your application no later than September 30th, 2020
      
      Where can I find out more?
      
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      • Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/
      • Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/
      • Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca/
        
        We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. We will ensure that individuals with disabilities are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Keywords: AstraZeneca, Washington DC , Research Scientist/ Senior Research Scientist, Other , Gaithersburg, DC