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Scientist I/II, Analytical Sciences - Mass Spectrometry

Company: AstraZeneca
Location: Gaithersburg
Posted on: October 19, 2020

Job Description:

Scientist I/II

Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then youre our kind of person.

About AstraZeneca in Gaithersburg, MD:

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where youll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

Summary of the group:

In Analytical Sciences in Gaithersburg, MD youll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients lives. Were constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. Were pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And were industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.

Main Duties & Responsibilities:

In this role, the Scientist I/II will need to develop and implement various mass spectrometry-based methods for the identification and quantification of product variants to support process development, product characterization, CQA assessment and actively participate in cross-functional teams. He / She will be responsible for providing high quality data to support the characterization of biopharmaceuticals, such as recombinant proteins, bispecific antibodies, antibody drug conjugates and aid in drafting of CMC documents for regulatory submissions.


  • Support product characterization using various mass spectrometry-based approaches, including peptide mapping, disulfide bond mapping, intact mass, N-/O-linked glycosylation profiling, de novo sequencing etc.
  • Keep accurate records of all experiments, data, equipment logs and troubleshoot the instruments as necessary
  • Make detailed observations, data analyses and result interpretations
  • Present and discuss experimental results at group/project team meetings
  • Authorize SOPs and other technical documents
  • Familiarize with GLP and GMP requirements during biopharmaceutical product development

    Education & Experience Requirements:

    PhD, MS or BS in analytical science, chemistry, biochemistry or related fields, with an emphasis on protein mass spectrometry strongly preferred

    Scientist I:

    - PhD with some relevant experience preferred or a Masters and a minimum of 8 years of relevant experience or a BS and at least 10 years of relevant experience

    - 5+ years of hands-on experience of utilizing LC-MS/MS techniques for protein characterization

    Scientist II:

    - PhD with at least 3 years of relevant experience or Masters and a minimum of 8 years of relevant experience or a BS and at least 10 years of relevant experience

    - 5+ years of hands-on experience of utilizing LC-MS/MS techniques for protein characterization

    Required Skills:

    • Extensive experience on operating and maintaining different mass spectrometric instruments
    • Experience in utilizing data analysis software such as Xcalibur, MassLynx, BioPharma Finder, Protein Metrics, UNIFY, Proteome Discoverer, Genedata, ProMass etc.
    • Experience on characterization of protein glycosylation using LC-MS/MS
    • A strong track record of success

      Desired Skills:

      • Experience with biopharmaceutical development in the biotech or pharmaceutical industry
      • In-depth knowledge in mass spectrometry and separation science
      • Excellent communication skills, both written and verbal
      • Instinctive team player with excellent people skills
      • Experience in ETD MS/MS, hydrogen-deuterium exchange (HDX) MS, nanoLC-MS, host cell protein (HCP) analysis by LC-MS, on-line Interfacing SEC-MS, IEC-MS, CE-MS (e.g. ZipChip), ion mobility MS for higher-order structure (HOS) analysis, is a plus

        Why AstraZeneca?

        At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means were opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

        So, whats next!

        Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope its yours.

        Where can I find out more?

        Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

        Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

        Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

Keywords: AstraZeneca, Washington DC , Scientist I/II, Analytical Sciences - Mass Spectrometry, Other , Gaithersburg, DC

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