Director, Operations IT – Global Biologics
Company: AstraZeneca
Location: Montgomery Village
Posted on: February 20, 2026
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Job Description:
Leverage technology to impact patients and ultimately save
lives. If you have expertise and passion for information technology
and want to shape IT strategy in a science-led company turning
ideas into life-changing medicines, this role at AstraZeneca offers
that opportunity. This position is based out of Gaithersburg, MD,
and will have primary responsibility for supporting our
manufacturing site in Philadelphia. About Operations IT Operations
IT is a global capability partnering with the Global Operations
organization across Pharmaceutical Technology Development,
Manufacturing & Global Engineering, Quality Control,
Sustainability, Supply Chain, Logistics, Global External Sourcing,
and Procurement. We operate from hub sites in the UK, Sweden, US,
and China, and Global Technology Centers in India and Mexico.
Accountabilities IT Strategy and Digital North Star: Define and
communicate the digital vision for Global Biologics (Philadelphia);
translate business objectives into sequenced initiatives and
measurable outcomes. GTO Partnership and Tech Transfer Enablement:
Partner with Global TechOps to standardize and digitize tech
transfer artifacts and workflows; improve right-first-time delivery
and compliance across Biologics sites. Portfolio Ownership: Lead
the Portfolio & Resource Mgmt. for Ops IT Global Biologics;
prioritize Run/Grow/Transform Demands & Investments, manage
dependencies, and ensure benefits realization are aligned to
strategic goals across Bio network sites Delivery Leadership:
Orchestrate cross-functional squads and vendors to deliver MES,
LIMS, QMS, ERP, data/analytics/AI capabilities; maintain sprint
discipline, readiness gates, and timely compliant go-lives.
Governance and Risk Management: Establish decision-focused
governance; maintain RAID logs; manage risk, cybersecurity, data
integrity, and CSV controls embedded in delivery. Stakeholder
Engagement: Build strong relationships with Site Leadership,
MS&T, QA, Operations, and Global functions; drive transparent
communication and adoption. Financial Management: Own the MTP
budgeting, forecasting and CapEx/OpEx control for the portfolio;
track ROI and ensure audit readiness. Operational Excellence:
Combine digital solutions with Lean practices to reduce cycle time,
improve quality/yield, and enhance batch release predictability. AI
& Data Strategy Insights: Advance data integration, master data,
and analytics; enable decision-quality data, dashboards, and
AI-assisted use cases at the site. Change Management and
Enablement: Lead training, communications, and business readiness;
create playbooks to scale digital/AI capabilities across teams and
sites. Talent Development: Mentor BAs in the team; uplift business
analysis practice, agile delivery, and storytelling standards
across the team. Essential skills and experience Education:
Bachelor’s degree. Experience: Minimum 10 years relevant
experience; regulated environment exposure. IT Business Partnership
& Analysis Mastery: Partner closely with business leaders to
translate strategy into outcomes; apply advanced BA techniques to
drive change—process mapping, requirements engineering, stakeholder
alignment, and quantified benefits. Complex Systems Delivery:
Proven success delivering outcomes across integrated platforms
(MES, LIMS, QMS, ERP, data/analytics) using creative and strategic
thinking. Stakeholder Management: Strong engagement, communication,
influencing, and executive presentation skills; effective virtual
collaboration. Risk and Compliance: Experience managing high levels
of risk, applying CSV, cybersecurity, data integrity, and
multi-functional judgment. Vendor Management: Track record of
managing third-party suppliers/vendors and SOWs. Coaching and
Leadership: Experience mentoring and developing others; shaping
practices and ways of working. AI and Advanced Analytics: Hands-on
experience identifying and delivering AI-enabled use cases,
familiarity with prompt design, model evaluation, data governance,
and responsible AI practices; ability to integrate AI into
operating rhythms and measure impact (adoption, cycle-time,
quality). Desireable skills and experience Pharmaceutical Sector
Exposure (Nice to Have): Familiarity with pharmaceutical
manufacturing or operations is beneficial, though not required. AI
and Advanced Analytics: Hands-on experience identifying and
delivering AI-enabled use cases, familiarity with prompt design,
model evaluation, data governance, and responsible AI practices;
ability to integrate AI into operating rhythms and measure impact
(adoption, cycle-time, quality). The annual base pay for this
position ranges from 151,177.60 - 226,766.40 USD Annual (80% -
120%). Hourly and salaried non-exempt employees will also be paid
overtime pay when working qualifying overtime hours. Base pay
offered may vary depending on multiple individualized factors,
including market location, job-related knowledge, skills, and
experience. In addition, our positions offer a short-term incentive
bonus opportunity; eligibility to participate in our equity-based
long-term incentive program (salaried roles), to receive a
retirement contribution (hourly roles), and commission payment
eligibility (sales roles). Benefits offered included a qualified
retirement program [401(k) plan]; paid vacation and holidays; paid
leaves; and, health benefits including medical, prescription drug,
dental, and vision coverage in accordance with the terms and
conditions of the applicable plans. Additional details of
participation in these benefit plans will be provided if an
employee receives an offer of employment. If hired, employee will
be in an “at-will position” and the Company reserves the right to
modify base pay (as well as any other discretionary payment or
compensation program) at any time, including for reasons related to
individual performance, Company or individual department/team
performance, and market factors. When we put unexpected teams in
the same room, we unleash bold thinking with the power to inspire
life-changing medicines. In-person working gives us the platform we
need to connect, work at pace and challenge perceptions. Thats why
we work, on average, a minimum of three days per week from the
office. But that doesnt mean were not flexible. We balance the
expectation of being in the office while respecting individual
flexibility. Join us in our unique and ambitious world. Why
AstraZeneca: Here, technology and science come together to move
faster for patients. You will join a community that values
ownership and experimentation, where hackathons, modern data
platforms and real manufacturing challenges create meaningful
outcomes. We blend ambition with kindness, placing unexpected teams
in the same room to spark new ideas, and we back that with the
scale and investment to deliver across the enterprise. Your
leadership will be visible—from streamlining batch release to
enabling AI-powered decisions—while you grow alongside colleagues
who share a curiosity to learn and the courage to challenge the
status quo.
Keywords: AstraZeneca, Washington DC , Director, Operations IT – Global Biologics, IT / Software / Systems , Montgomery Village, DC
